|
|
Main menu for Browse IS/STAG
Course info
KME / MFS
:
Course description
Department/Unit / Abbreviation
|
KME
/
MFS
|
Academic Year
|
2023/2024
|
Academic Year
|
2023/2024
|
Title
|
Modelling of Physiological Systems
|
Form of course completion
|
Exam
|
Form of course completion
|
Exam
|
Accredited / Credits
|
Yes,
5
Cred.
|
Type of completion
|
Combined
|
Type of completion
|
Combined
|
Time requirements
|
Lecture
3
[Hours/Week]
Tutorial
2
[Hours/Week]
|
Course credit prior to examination
|
Yes
|
Course credit prior to examination
|
Yes
|
Automatic acceptance of credit before examination
|
No
|
Included in study average
|
YES
|
Language of instruction
|
Czech, English
|
Occ/max
|
|
|
|
Automatic acceptance of credit before examination
|
No
|
Summer semester
|
0 / -
|
0 / -
|
0 / -
|
Included in study average
|
YES
|
Winter semester
|
0 / -
|
0 / -
|
0 / -
|
Repeated registration
|
NO
|
Repeated registration
|
NO
|
Timetable
|
Yes
|
Semester taught
|
Winter semester
|
Semester taught
|
Winter semester
|
Minimum (B + C) students
|
10
|
Optional course |
Yes
|
Optional course
|
Yes
|
Language of instruction
|
Czech, English
|
Internship duration
|
0
|
No. of hours of on-premise lessons |
|
Evaluation scale |
1|2|3|4 |
Periodicity |
každý rok
|
Evaluation scale for credit before examination |
S|N |
Periodicita upřesnění |
|
Fundamental theoretical course |
No
|
Fundamental course |
Yes
|
Fundamental theoretical course |
No
|
Evaluation scale |
1|2|3|4 |
Evaluation scale for credit before examination |
S|N |
Substituted course
|
None
|
Preclusive courses
|
N/A
|
Prerequisite courses
|
N/A
|
Informally recommended courses
|
KME/MK and KME/BIM
|
Courses depending on this Course
|
KIV/MISZ
|
Histogram of students' grades over the years:
Graphic PNG
,
XLS
|
Course objectives:
|
Student will become acquainted with
- Basic physiological systems of the human body and their models,
- description of physiological processes of individual subsystems from the perspective of mathematical modeling.
|
Requirements on student
|
Credit Requirements:
Elaboration of semestral work at the appropriate level.
Exam Requirements:
Knowledge of the lectured matter, pre-requisits and co-requisits, formulation and solving of selected problems in tissue and organ physiology.
|
Content
|
1) Cellular structure and mechanics, microreology, classification of processes in cells.
2-3) Introduction to modeling of cell membrane electrochemical processes, membrane potentials, reaction kinetics, transpot and diffusion, volume regulation. Hodggkin-Huxley model, calcium dynamics.
4-5) Cell motion and Cellular motors. Motion along microtubules (kinesin, dynein) and actin filaments (myosin). Actomyosin movement (cell division, muscle contraction), proton pump, cytoskeleton physiology.
6) Intercellular communication, chemical synapse, dendritic conduction, electric current in neurons, calcium waves, regulation of cellular processes.
7) Description of cardiac rhythm physiology, description of oscillations, pacemakers, arrhythmia, defibrillation.
8) Models of muscle contraction, differences in the physiology of smooth and striated muscles in the context of modeling. Huxley's model.
9) Microcirculation in the vascular system, modeling approaches. Blood rheology and hemodynamics, transport of oxygen and other substances.
10-11) Physiology of cardiovascular and lymphatic system, models of blood circulation in tissues. Pulmonary physiology, breathing, thermoregulation.
12) Modeling of tissue reconstruction and bone growth. Physiological processes, stimulation by mechanical stress.
13) Metabolism of hepatocytes and binding to microcirculation.
|
Activities
|
|
Fields of study
|
|
Guarantors and lecturers
|
|
Literature
|
|
Time requirements
|
All forms of study
|
Activities
|
Time requirements for activity [h]
|
Attendance on a field trip (number of real hours - maximum 8h/day)
|
3
|
Preparation for an examination (30-60)
|
45
|
Contact hours
|
62
|
Graduate study programme term essay (40-50)
|
20
|
Total
|
130
|
|
Prerequisites
|
Knowledge - students are expected to possess the following knowledge before the course commences to finish it successfully: |
orientovat se v oblasti mechaniky kontinua a biomechaniky |
vyjmenovat základní anatomické celky lidského těla |
orientovat se v oblasti biomechaniky, popsat základní funkce orgánů. |
orientovat se v oblasti diferenciálních rovnic |
orientovat se v oblasti tenzorového, diferenciálního a integrálního počtu |
orientovat se v oblasti numerických metod a algoritmizace |
Skills - students are expected to possess the following skills before the course commences to finish it successfully: |
řešit základní typy diferenciálních rovnic analyticky i pomocí adekvátních numerických metod |
řešit problémy a úlohy v mechanice poddajných těles a tekutin |
využívat software pro statistické zpracování dat (experimentálních) a jejich grafické zpracování |
využívat některý programovací jazyk pro numerické řešení jednodušších úloh z oblasti diferenciálních rovnic a nelineárních algebraických rovnic |
Competences - students are expected to possess the following competences before the course commences to finish it successfully: |
N/A |
|
Learning outcomes
|
Knowledge - knowledge resulting from the course: |
vysvětlit stavbu buňky a základní procesy na buněčné úrovni |
popsat elektro-difúzní procesy a kinetiku chemických reakcí v kontextu fyziologických procesů |
vysvětlit mezibuněčnou komunikaci, chemické synapse, eletrický tok v neuronech, regulaci buněčných procesů, buněčné motory a fyziologii cytoskeletu. |
orientovat se v modelech svalové kontrakce, měkkých tkáních a tkáně kostí |
orientovat se v principech tkáňového růstu a remodelace vybraného typu tkání, zejména kostí. |
vysvětlit fyziologii srdečního rytmu, popsat oscilace, činnost pacemakerů, arytmii a defibrilaci. |
orientovat se v popisu mikrocirkulace v cévním systému, transportu kyslíku a jiných látek. |
vysvětlit fyziologii kardiovaskulárního a lymfatického systému, modely prokrvení tkání, fyziologii dýcháním a termoregulaci.
|
Skills - skills resulting from the course: |
využívat odborných znalostí pro řešení některých jednodušších úloh z oblasti fyziologie tkání |
pro daný případ (problém) analyzovat nároky na komplexnost modelu fyziologického systému, vybrat jeho rozhodující vlastnosti a jevy, které by měl popisovat |
orientovat se v odborné literatuře zaměřené na modelování fyziologie tkáňových systémů a zpracování experimentálních studií |
formulovat a řešit jednodušší úlohy pro simulace fyziologických procesů v tkáních. |
samostatně vyhledávat relevantní informace o aktuálních vědeckých poznatcích v oblasti modelování fyziologických systémů |
Competences - competences resulting from the course: |
N/A |
N/A |
|
Assessment methods
|
Knowledge - knowledge achieved by taking this course are verified by the following means: |
Combined exam |
Seminar work |
Skills - skills achieved by taking this course are verified by the following means: |
Combined exam |
Seminar work |
Competences - competence achieved by taking this course are verified by the following means: |
Seminar work |
|
Teaching methods
|
Knowledge - the following training methods are used to achieve the required knowledge: |
Lecture |
Self-study of literature |
Field trip |
One-to-One tutorial |
Skills - the following training methods are used to achieve the required skills: |
Interactive lecture |
Practicum |
One-to-One tutorial |
Competences - the following training methods are used to achieve the required competences: |
Lecture |
Practicum |
|
|
|
|